On the other hand, the markers associated with quiescent HSCs, such as parathyroid hormone 1 receptor (PTH1R), were significantly downregulated in PSC/PBC liver tissues (p < 0.0001 PSC vs. healthy and p < 0.05 PBC vs. healthy), indicating increased activation of HSCs leading to elevated fractions for myofibroblast type cells (Figure 4C). Here, PTH1R is linked to primary biliary cholangitis.