A renal tissue analysis was performed as an internal control, considering that SGLT2is have mainly been used as antidiabetic drugs acting on the proximal convoluted tubule of the kidney (expressing SGLT-2), where they block the reabsorption of glucose and sodium, favoring the urinary excretion of glucose (7, 8), Subsequent studies have also demonstrated the expression of SGLT2 in cardiac tissues, broadening their clinical spectrum of action in the prevention of cardiovascular diseases (33, 34). Here, SLC5A2 is linked to cardiovascular disorder.