Among them, nucleophosmin1 (NPM1) especially attracted our attention, as it is one of the mostcommon mutated proteins in AML.28 To supportthat the inhibitory capacity of UCM-13369 observed in CSC cells (see Table S1) is mediated by NPM1, the compound wastested on OCI-AML3 and MOLM13 cell lines, as in vitro AML models bearing mutant (NPM1 C+) and wild-type (WT) protein,respectively. Here, NPM1 is linked to acute myeloid leukemia.