Among the different stem- and cancer-related proteins that wereablated by the compound (see Supplementary Excel file), NPM1 stands out as a particularly relevant protein inAML, a hematological disease with a high mortality rate.28 AML affects the hematopoietic system throughabnormal proliferation of myeloid cells in the bone marrow and ultimatelysuppresses the production of healthy blood cells. Here, NPM1 is linked to acute myeloid leukemia.