NPM1 and cancer: Among the different stem- and cancer-related proteins that wereablated by the compound (see Supplementary Excel file), NPM1 stands out as a particularly relevant protein inAML, a hematological disease with a high mortality rate.28 AML affects the hematopoietic system throughabnormal proliferation of myeloid cells in the bone marrow and ultimatelysuppresses the production of healthy blood cells.