Evidence that CRIM1 haploinsufficiency leads to defects in eye development in humans and mice suggests CRIM1 as a potential causative gene of Macrophthalmia, colobomatous, with microcornea (MACOM) and underscores the importance of CRIM1 in eye development (Beleggia et al., 2015). Here, CRIM1 is linked to colobomatous macrophthalmia-microcornea syndrome.