In addition, Nsd2 is downregulated in diabetes mellitus type 2 and has been shown to play a role in insulin secretion and glucose metabolism by regulating hexokinase 2 (HK2) and glucose-6-phosphate dehydrogenase (G6PD) (Wang et al., 2016; Shi et al., 2018). Here, HK2 is linked to type 2 diabetes mellitus.