Notably, tumour protein p53 (TP53) (43.50%) and dynein axonemal heavy chain 11 (DNAH11) (10.42%) emerged as the most frequently altered genes in breast cancer tumors, followed by T-box transcription factor 3 (TBX3) (4.98%), AKT serine/threonine kinase 1 (AKT1) (3.60%), and breast cancer gene 2 (BRCA2) (2.53%). The gene discussed is TBX3; the disease is breast cancer.