The top 10 genes with high incidence were PRKDC, BRCA2, BRCA1, FANCI, ERCC5, SLX4, PTCH1, MC1R, BARD1, and RET. The 30 genes were significantly enriched in the fanconi anemia pathway (P value 2.55e-13, FDR 5.15e-11) and mismatch repair (P value 2.40e-10, FDR 2.42e-8) (Supplementary Figure S2B). This evidence concerns the gene PRKDC and Fanconi anemia.