A study of 449 epithelial ovarian cancer gene mutations from Peking Union Medical College Hospital (18), including 28 HRR-related genes, 4 MMR genes, and 4 hereditary tumor-related genes, found that 107 patients carried BRCA1/2 germline mutations, the other 31 patients were carriers of germline mutations in other DDR-related genes, and all RAD51D germline mutation carriers were patients younger than 40 years. Here, BRCA1 is linked to ovarian carcinoma.