An exploration of the distribution of mutation sites within genes showed single or multiple hotspot mutations in high-incidence mutated genes (Figure 2), such as BRCA1: c.2566T>C (p.Y856H), BRCA2: c.10234A>G (p.I3412V), ERCC5: c.1586G>C (p.C529S), FANCI: c.2011A>G (p.I671V), PRKDC: c.10681T>A (p.L3561M), and BARD1: c.1075_1095del (p.L359_P365del), suggesting that these sites were associated with ovarian cancer occurrence in China. The gene discussed is ERCC5; the disease is ovarian carcinoma.