The top 10 genes with high incidence were PRKDC, BRCA2, BRCA1, FANCI, ERCC5, SLX4, PTCH1, MC1R, BARD1, and RET. The 30 genes were significantly enriched in the fanconi anemia pathway (P value 2.55e-13, FDR 5.15e-11) and mismatch repair (P value 2.40e-10, FDR 2.42e-8) (Supplementary Figure S2B). Here, ERCC5 is linked to Fanconi anemia.