This model could be used to calculate the probability of HCC occurrence for each cirrhosis patient—for example, a 46.36-year-old and alcohol-drinking male cirrhosis patient with 2.56 ng/mL of AFP, accepting antiviral therapy and HBeAg negative at diagnosis of cirrhosis, had a total score of about 273, and the respective 20-, 40-,60-,80-, and 100-month HCC incidences were about 4.1%, 10.5%, 16.9%, 24.1%, and 32.4% (Figure 4A). The gene discussed is AFP; the disease is Cirrhosis.