The AASL (age, albumin, sex, and liver cirrhosis)-HCC scoring system (12), real-world risk score for hepatocellular carcinoma (RWS-HCC) (13), and Chinese University (CU)-HCC score (14) were used for the prediction of HCC risk in CHB patients, taking cirrhosis into account. The gene discussed is ALB; the disease is hepatocellular carcinoma.