Therefore, we performed WGCNA analysis, GO and KEGG enrichment analysis, GSEA analysis through GC-related data in the GEO database, and through OS analysis, TCGA database analysis and IHC verification, we found that C1QB, FCER1G, FPR3 and TYROBP may be the core genes for the occurrence and development of GC, and their mechanism of action may involve toll-like receptor signaling pathway, neuroactive ligand-receptor interaction, lysosome, gastric acid secretion, cholesterol metabolism, INFγ response activation and oxidative phosphorylation suppression. Here, TYROBP is linked to gastric cancer.