Genes like COMMD5, COMMD7, and COMMD9 have also been confirmed to promote the dephosphorylation of ErbB2/HER2 or downstream molecules, such as PIAS or CXCL1, to participate in the regulation of non-small cell lung cancer, hepatocellular carcinoma, renal cell carcinoma, and pancreatic ductal adenocarcinoma 37. Here, COMMD5 is linked to hereditary clear cell renal cell carcinoma.