COMMD1, as the star molecule of the COMMDs family, has been confirmed to be involved in regulating the invasion, metastasis, and chemo-resistance of malignant tumors such as neuroblastoma, head and neck squamous cell carcinoma, lung cancer, colorectal cancer, glioblastoma, and melanoma cells 36, 37. This evidence concerns the gene COMMD1 and head and neck squamous cell carcinoma.