We analyzed the expression levels of Type I interferons and ISG genes in the tumor tissues of patients and normal control tissues, revealing a consistent upregulation of ISG genes, including ISG15, MX1, MDA5, IFIT2, IFIT3, IRF1 and IRF7, in the tumor tissues of patients with cholangiocarcinoma. Here, IFIT2 is linked to cholangiocarcinoma.