CD8A and neoplasm: İn the early stage of TIME formation, M1-like macrophages work as tumor growth suppressor 12, 13, partly by recruiting CD8+ T cell and NK cells through antigen presentation to the T-cell receptor (TCR) 14, also driving the release of chemokines (C-X-C motif chemokine ligand (CXCL) 9/10/11) derived from tumor cells to recruit NK cells 15.