It has been demonstrated that proteases within NETs, such as NE and matrix metalloproteinase 9 (MMP9), can cleave and reshape laminin, exposing a binding site that acts as an activation site for integrin α3β1, leading to the activation of FAK/ERK/MLCK/YAP signaling in cancer cells and their reawakening, promoting proliferation. The gene discussed is LAMB2; the disease is cancer.