NOTCH1 and cancer: However, while these studies lack comprehensive insight into the heterogeneous response to ASPH inhibition because they primarily focused on a single cancer type, and a limited number of signaling pathways, our study compared 6 cell lines representing 3 cancer types and performed a complex characterization of cellular processes affected by ASPH inhibition, including novel analyses of activated Notch1 localization, nuclear morphology, and cell cycle progression.