NOTCH1 and neoplasm: The present study aimed to investigate the effect of ASPH inhibitors on established pathways, with a particular emphasis on the canonical and noncanonical Notch1 signaling pathways in human tumor cell lines of different origins, including cervical (HeLa, SiHa, and CaSki), pharyngeal (FaDu and Detroit 562), and breast (MCF-7) cancer cells.