As shown in Figures 4D-F, exosomes derived from the HCT8R cells (HCT8R-exo) significantly increased the expression of CAFs markers compared to the HCT8 exosomes (HCT8-exo), indicating that exosomes from chemoresistant and chemosensitive tumor cells induce different types of CAFs. Here, TBX1 is linked to neoplasm.