KMT2A and acute myeloid leukemia: Fourth, high-risk cytogenetics (particularly lysine methyltransferase 2A (KMT2A) may be predictive of a higher rate of post-CAR T-cell relapse and, in particular, lineage-switching to AML,101 though this association has not been consistently observed, and some studies show no difference between patients with versus without high-risk cytogenetics.100