Although this study revealed no differences in STAT3 and PD-L1 expression between HL and NHL and no significant correlation between STAT3 and PD-L1 expression in HL and NHL, this may serve as the basis for understanding the role of STAT3 and PD-L1 in the regulation of HL and NHL, which may be useful for further research targeting STAT3 and PD-L1 immunotherapy in HL and NHL. Here, CD274 is linked to non-Hodgkin lymphoma.