While infection with both RUB and RAY strains shows upregulation of the gene signature for ‘Interferon mediated signaling pathway’ (P-value 0.009 and 0.049) and ‘Receptor signaling via STAT’ (P-value 0.006 and 0.039), a known downstream effector of interferon, the RUB strain was specifically enriched for ‘cellular response to virus’ (P-value 0.019), supporting the existence of specific host biological viral-response against Ao. The gene discussed is SOAT1; the disease is infection.