It has been reported to result in cell cycle arrest, apoptosis induction, decreased cell proliferation, migration, and reduced adhesion in many cancer cell lines, primarily by controlling various signaling pathways, including EGFR/Jak2/STATs, TGF-β, and NF-Kβ, or suppressing the PKM2 glycolytic enzyme. The gene discussed is NFKB1; the disease is cancer.