To gain insights into the cellular and molecular mechanisms underlying the protective effects of AXL inhibition during MASH pathogenesis, we employed cytometry by time-of-flight (CyTOF), also known as mass cytometry, and transcriptomic analysis on liver samples from mice fed with MASH-promoting diet and/or the AXL inhibitor bemcentinib. This evidence concerns the gene AXL and metabolic dysfunction-associated steatohepatitis.