TNF and bacterial infectious disease with sepsis: This rationale could explain the wide distribution of the transcriptomic profiles within the Bacteremia group, as the concerted activation of IFN-gamma, TNF-alpha, and related pathways would be suppressed among those in the category with transcriptomic profiles most similar to Healthy Controls (Cluster 1), low in those Bacteremia group members that formed Cluster 2, and high in those found in Cluster 3.