CD8A and neoplasm: Moreover, tumor-derived cGAMP triggers a STING-mediated interferon response in non-tumor cells and activates NK cells, mediating the clearance of CD8+ T cell-resistant tumors in response to STING agonists, underscoring the broad applicability of STING activation in promoting antitumor responses across various tumor contexts (70, 71, 82, 83).