Moreover, tumor-derived cGAMP triggers a STING-mediated interferon response in non-tumor cells and activates NK cells, mediating the clearance of CD8+ T cell-resistant tumors in response to STING agonists, underscoring the broad applicability of STING activation in promoting antitumor responses across various tumor contexts (70, 71, 82, 83). The gene discussed is STING1; the disease is neoplasm.