IFNG and osteoporosis: Compared with IFNγR1(+/+) mice, IFNγR1(-/-) mice had reduced bone mass and bone mineral density and exhibited significant osteoporotic features. In addition, administration of IFN-γ to OVX female mice significantly improved bone remodeling, bone mechanical properties, bone microarchitecture, and bone mass, and ameliorated osteoporosis in OVX mice.