Rhabdomyolysis was defined as patients having a history of muscle injury accompanied by elevated creatine kinase (CK) level; mild rhabdomyolysis was described as having a blood creatine phosphokinase (CPK) of 300-1000 IU/L on the first day of admission, moderate rhabdomyolysis (crush injury) was defined as having blood CKP level above 1000 IU/L, crush syndrome was defined as having blood raised CPK level accompanied with systemic complication (acute kidney injury (AKI), sepsis, organ failure or respiratory failure) [7]. This evidence concerns the gene PIK3C2A and rhabdomyolysis.