KLK3 and cancer: The Gleason score for each positive core on both 12-core prostate biopsy procedures was 6, and the Prostate Imaging-Reporting and Data System (PI-RADS) score was 2, indicating low metastatic risk and slow growth [6] and low likelihood of developing clinically significant cancer [7]. The patient maintained active surveillance due to the low relative risk and periodically visited his urologist between 2018 and 2023, with frequent testing of prostate-specific antigen (PSA) levels.