Several clinical characteristics are associated with AFP-producing adenocarcinomas and include early multi-organ metastasis, especially liver/lymph node metastases at the time of diagnosis, as well as multidrug resistance to therapy. Both of these lead to a rapidly worsening clinical state after diagnosis and correlate to a much inferior prognosis in AFP-producing adenocarcinoma originating from the gastrointestinal tract (APA-GI) compared to non-AFP-producing adenocarcinomas of the gastrointestinal tract [7]. Here, AFP is linked to adenocarcinoma.