Knowing the fact that the same 13q LOH is commonly deleted in AFPGA and is also frequently deleted in AFP-producing hepatocellular carcinoma (AFPHCC) strengthens the possibility that high fractional allelic loss in 13q could be responsible for the regulation of AFP synthesis; therefore, 13 qLOH and additional alteration of the remaining allele may silence or downregulate the gene and produce AFP [5,9,10]. The gene discussed is AFP; the disease is hepatocellular carcinoma.