We have described that HF stimulation, through a still-unknown component, probably F-actin or another protein related to necrotic cells, described in proteomic analysis of HF (Zeghir-Bouteldja et al., 2017; Schulz et al., 2018; Canton et al., 2021; dos Santos et al., 2022), induces downregulation of CLEC9A and CD205 in the cell membrane of BMDCs and this effect was not reversed with the use of EDTA. This evidence concerns the gene LY75 and hydrops fetalis.