have showed that exogenous overexpression of AIM2 in HCC cells suppressed mammalian target of rapamycin (mTOR)-S6K1 signaling pathway and further inhibited proliferation and invasion of HCC cells, and block of AIM2 in HCC cells induced mTOR-S6K1 signaling pathway activation and therefore promoted HCC progression (Ma et al., 2016). Here, AIM2 is linked to hepatocellular carcinoma.