Moreover, NF-κβ1 activation has strengthened the activation of the Notch1 pathway, and once NF-κβ1 and Notch1 are activated, they inhibit the expression of peroxisome proliferator-activated receptor-γ (PPARγ), and therefore, they enhance tumor proliferation [18,19]. This evidence concerns the gene NFKB1 and neoplasm.