NOTCH1 and neoplasm: Finally, silencing Notch1 showed a synergistic effect with gemcitabine, ensuring the cross mechanism that Notch1 plays to enhance the gemcitabine sensitivity on PANC-1 cells; with decrement of the viability of gemcitabine-treated cells from 59.72% alone to a 35,43% when combined with Notch1 In other studies, Notch1-activated pathways showed higher expression of drug efflux pump which contributes to higher resistance of gemcitabine on tumor cells.