HOL also activated the phosphorylates FOXO3a, phosphoinositide 3-kinase/Akt pathway, induced the cell death and mitochondrial dysfunction and then downregulated FOXO3a's target genes in human CRC cells (DLD1) but not on normal colon cells (1807) by producing ROS in CRC cells [70]. Here, FOXO3 is linked to colorectal carcinoma.