The top 10 important pathways were relaxin signaling pathway, fluid shear stress and atherosclerosis, AGE-RAGE signaling pathway in diabetes complications, bladder cancer, diabetic cardiomyopathy, proteoglycan, lipids and atherosclerosis in cancer, cancer pathway, PI3K-Akt signaling pathway, and HIF-1 signaling pathway. The gene discussed is AKT1; the disease is diabetes mellitus.