Top hits (p < 1 × 10−4) include HLA-C, which contains the MS protective variant HLA-Cw*05; the BTB-Kelch–related protein KLHL7, which contains risk variants for Parkinson disease49; and PLEK, which has suggestive association with MS risk50 and significant association with spinal cord atrophy in PwMS.51 Here, PLEK is linked to myeloid sarcoma.