In addition, rs11755689 has prior associations with LDL cholesterol and omega-6 polyunsaturated fatty acid, as well as levels of various phospholipids (eTable 20B).42 Cholesterol metabolism is associated with various MS disease outcomes, including disability severity and T2 lesion load.43 Rs28672722 is located near HLA-DQB1, which is associated with MS AAO at gene level (p = 0.007), and the SNP has been associated with allergies and cervical cancer (eTable 20C). Here, HLA-DQB1 is linked to Allergy.