IL6 and myeloid sarcoma: IL-6 has been associated with MS risk and disease activity,44,45 and while body-shape is not causally associated with MS risk, it may be a proxy for body mass index which is an established MS risk factor and driver of poorer outcomes.35,46 Thus, it is possible these relationships with IL-6 and body shape might contribute to the observation relationships discussed above future work should consider comprehensive mediation analyses.