NLRP3 and periodontal disorder: Recent findings have shown that in cases with moderate-to-severe and generalized periodontal breakdown, increased salivary levels of NLRP3, ASC, and IL-1β were recorded, as compared to healthy controls (Isaza-Guzman et al., 2017), suggesting that NLRP3 may represent an independent predictor of disease risk during different stages of periodontal disease.