Since 25‐HC is known to regulate sterol regulatory element‐binding protein (SREBP) expression, and lipid metabolic disorder plays a major role in podocyte injury in DKD,[20] we also examined SREBP1 expression in podocytes but we found that treatment of 25‐HC did not change SREBP1 expression in podocytes (Figure S7, Supporting Information). This evidence concerns the gene SREBF1 and diabetic kidney disease.