Although several studies reported high expression levels of 5-LOX in meningioma cells suggesting a putative role of 5-LOX in meningioma tumorigenesis [21, 73–75], for the first time we have demonstrated a significant correlation between the expression of 5-LOX and presence of the T cell immune infiltration in meningioma tumours. This evidence concerns the gene ALOX5 and meningioma.