MAPT and early-onset autosomal dominant Alzheimer disease: Initially focusing on the clearance of pathogenic proteins including amyloid beta and tau implicated in neurodegenerative conditions such as Alzheimer’s disease, these studies have provided a key mechanistic explanation for the observed clinical association between risk factors such as aging, cerebrovascular disease, traumatic brain injury, and sleep disruption with risk of dementing neurodegenerative conditions [8].