The talk did therefore focus on three genes; (1) cnm gene of carcinogenic Streptococcus mutans involved in cerebral microbleeds and hemorrhagic stroke, (2) RNF213 gene and the RNF213 p.R4810K variant associated with the emerging disease concept RNF213-related vasculopathy common in East Asia, and (3) NOTCH3 gene and its mutations causing Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL). The gene discussed is RNF213; the disease is CADASIL.