This indicated that offspring genotype ratios were not significantly different from expected Mendelian ratios at either PN1 (n=101) or e17.5 (n=124) (Additional file 2: Table S2), even though pups lacking Insr expression are destined to die within a few days post-parturition of diabetic ketoacidosis [43, 45, 50]. This evidence concerns the gene INSR and diabetic ketoacidosis.