Taken together, our morphometric analyses link PlGF/sFlt1circ and tissue PlGF expression to the presence and extent of NI in the retrospective and prospective PDAC cohorts and support the notion that PlGF/sFlt1circ may serve as a quantitative serum biomarker of NI, prompting us to experimentally explore the function of PlGF at the tumor-nerve interface. Here, PGF is linked to neoplasm.