Several of USP28’s substrates, such as the transcription factors c-Myc, HIF1α, and ΔNp63, the lysine-specific demethylase LSD1 and the helicase RecQ5, act as oncogenes in a variety of cancers rendering USP28 itself an essential oncogene (Popov et al, 2007; Wu et al, 2013; Du et al, 2019; Prieto-Garcia et al, 2020; Wang et al, 2021b). This evidence concerns the gene USP28 and cancer.