Results supporting this hypothesis are also presented in a model which shows that upon SARS-CoV-2 infection, there is downregulation of Ca2+ pumps on the cell membrane (ATP2B1) and the endoplasmic reticulum (ATP2A1) thus increasing the intracellular Ca2+ levels during viral infection and replication (Fig. 5D). This evidence concerns the gene ATP2B1 and viral infectious disease.