Of importance, in a cohort of infected symptomatic patients (197 patients affected by severe COVID-19 and 370 asymptomatic cases), we identified a rare homozygous (0.03% allele frequency in our analyzed cohort) intron variant in the ATP2B1 locus (i.e., rs111337717) as a novel genetic factor responsible for severe COVID-19 predisposition (Table 1). The gene discussed is ATP2B1; the disease is COVID-19.