Wu et al. found that mJPYZ can reduce the content of exosomal PKM2 in GC cells, thereby reducing the transport of exosomal PKM2 from tumor cells to macrophages, and alleviating the differentiation of M2-TAM induced by exosomal PKM2 in the tumor microenvironment, ultimately inhibiting the progression of GC [56]. This evidence concerns the gene PKM and gastric cancer.