Furthermore, it has been observed that in breast cancer cells, the P53–P21WAF1/CIP1, ERK1/2 MAPK, p27KIP1, BRCA1, and NF-κB pathways play critical roles in response to metabolic stress following perturbations in FAS-dependent de novo fatty acid biosynthesis30. The gene discussed is CDKN1A; the disease is breast cancer.