INS and Insulin resistance: The novelty of the current work lies in (a) demonstrating that the adipocyte is a key cell type mediating the effect of IRF3 on insulin action, (b) showing definitively that the effect on insulin sensitivity is independent of weight changes, and most importantly, (c) identifying a specific molecular link between IRF3 and insulin resistance (i.e., reduction of FAHFAs by promoting expression of a FAHFA hydrolase).