YAP1 and osteoarthritis: YAP and TAZ are the nuclear transducers of the Hippo pathway.49 Dupont et al. identified YAP/TAZ as sensors and mediators of mechanical cues instructed by the cellular microenvironment.24 Deng et al. established a reciprocal antagonism between Hippo-YAP/TAZ and NF-κB signaling in regulating the induction of matrix-degrading enzyme expression and cartilage degradation during osteoarthritis pathogenesis.50 Our findings suggest that loss of Yap1 in chondrocytes accelerates CEP degradation and initiates its remodeling.