YAP and TAZ are the nuclear transducers of the Hippo pathway.49 Dupont et al. identified YAP/TAZ as sensors and mediators of mechanical cues instructed by the cellular microenvironment.24 Deng et al. established a reciprocal antagonism between Hippo-YAP/TAZ and NF-κB signaling in regulating the induction of matrix-degrading enzyme expression and cartilage degradation during osteoarthritis pathogenesis.50 Our findings suggest that loss of Yap1 in chondrocytes accelerates CEP degradation and initiates its remodeling. Here, NFKB1 is linked to osteoarthritis.