During our comparative analysis, we also found that prognostic CoGAPS pattern 15 is enriched for a class of granulocytes in severe COVID-19 that have been designated “developing neutrophils” that express genes characteristic of low density immature pre- and pro- neutrophils such as DEFA3, CAMP and LCN2 (Fig. 5a–e)25,28. This evidence concerns the gene DEFA3 and COVID-19.