As an important pro-fibrotic substance, OPN promotes CF attachment to the ECM, and CF growth and ECM production.242 Adiponectin (APN) is an adipokine with anti-inflammatory function that can inhibit the Ang-II-induced inflammatory response by activating macrophage autophagy, thereby reducing the degree of myocardial fibrosis.243 However, its levels are significantly reduced in diabetic hearts, increasing myocardial fibrosis.243,244. This evidence concerns the gene AGT and Myocardial fibrosis.