The baseline characteristics of the 5145 participants randomized in Look AHEAD have been described.12 The mean age was 59 years, 60% were women, 63% were non-Hispanic white, 14% had a history of CVD, 16% were treated with insulin, and 4% had high risk or very high risk of CKD according to KDIGO criteria.9 Characteristics are stratified by baseline age in table 1. This evidence concerns the gene INS and chronic kidney disease.