PRKCA and pachyonychia congenita: Similarly, in PC cells, PKCα silencing increased p-AKT (Ser473) and p-β-catenin (Ser552) levels that were consistent with the increase of PKCα after NDRG1 overexpression decreasing p-AKT (Ser473) and p-β-catenin (Ser552; Fig. 9).