GSK3B and Familial prostate cancer: However, similar to our previous investigation examining colon and prostate cancer cells (13), NDRG1 overexpression in PANC-1 cells significantly increased (p < 0.001) the expression of the GSK-3β-binding protein, frequently rearranged in advanced T-cell lymphoma (FRAT1), relative to VC cells (Fig. 1A).