Around 50%–60% of patients carry pathogenic variants in the CLCN5 gene (Dent disease type 1 [DD1] Online Mendelian Inheritance in Man 300009), and 10%–15% of patients carry pathogenic variants in the OCRL gene (Dent disease type 2 Online Mendelian Inheritance in Man 300555). This evidence concerns the gene CLCN5 and Dent disease.