Consequently, Gene Set Variation Analysis (GSVA) analysis showed that ITGB1 correlated with the TGF-β signaling pathway, extracellular matrix (ECM) receptor interaction, pathway in cancer, and regulation of actin cytoskeleton (Fig. 5D); ITGB3 correlated with endocytosis, focal adhesion, ECM receptor interaction, regulation of actin cytoskeleton, and apoptosis (Fig. 5E); while ITGB8 correlated with apoptosis, Janus kinase–signal transducer of activation (JAK-STAT) signaling pathway, ECM receptor interaction, focal adhesion, and mismatch repair (Fig. 5F). The gene discussed is ITGB8; the disease is cancer.